It's a little hard to understand exactly what you are asking however I'll try. Jakusonfire is great at this stuff so hopefully he will confirm. 
-  As Jakusonfire has said, at a minimum you need to connect the mps by USB once to download the latest firmware & configure the device. Once you have done this I highly recommend you disconnect everything particularly power including the mains from the devices & AQ5, reboot the computer, and reconnect. Maybe overboard but as Namron on another forum has guided this avoids some problems (which I have experienced myself). 
-  once it is configured you can connect by Aquabus, USB, or both. If Aquabus only you need the 4-pin cable for power. Also this needs to be always on the Aquabus High channel. Get as many cable splitters as you need as you just daisy-chain these devices together.  If you are on Aquabus only the device will show up in Aquasuite on the AQ5 tab. 
-  if you are on both the mps will show up on the AQ5 tab in Aquasuite and on its own tab. You have more options for monitoring for sure. 
-  if on USB only it will not be on the AQ5 tab (I think).  I have always had either Aquabus or both connections. 
Have fun.