FWIW, I agree with Teasuti – It could be USB related. Check Universal Serial Bus controllers and Universal Serial Bus devices in Device Manager to see if there are any USB devices that failed to enumerate or have any error message. The Octo should show up as a Universal Serial Bus device. Download
USB Device Tree Viewer that will show the entire USB bus structure and port speeds, and flag a bunch of different problem codes. USB is quite resilient, but there is a lot going on under the hood. If a device is storming the bus or messing up the USB Stack, it can cause unpredictable problems with other USB devices.
I have an NVMe-USB bridge external drive carrier with a Realtek RTL9210B controller that will try to negotiate a 10Gbps link and work, but CRC errors build up until the USB Host and NVMe-USB Bridge controller initiate the Recovery Active state. Retrain is attempted for 12ms, after which the USB Host reduces the link speed to the next lower level and re-enumerates the NVMe-USB bridge controller, first at 5Gbps, and if that link is not stable, at 480Mbps. This will happen over and over again. The OS is loading and unloading drivers, the CPU is processing USB error signals. It sometimes causes problems with headset audio and other USB drives. It took me a while to figure out what was causing it.
You may have some other USB device that is misbehaving, and the problem is manifesting as communication problems between your Octo and Aquasuite. Disconnecting and reconnecting or rebooting both result in the Octo being re-enumerated, the USB Stack is happy, and the problem goes away, for a while. Is your High Flow Next or Farbwerk360 having communication problems? Have you tried sending new LED data to the Farbwerk or altering the High Flow Next LCD menus? If they are also behaving erratically when new data or configuration changes are sent, the same USB bus issue is probably causing it.