The only drawback is, the Farbwerk`s will not be sync`ed with the Quadro.
The 2 Farbwerk 360s will not be in sync either. I learned the hard way that RGBpx ports on different devices cannot be synched when I put 2 x Farbwerk360s in my last build. RGBpx port sync between devices, at least between 2 Farbwek360s, is something I asked about several times. A few years ago Aquacomputer said they were going to add RGBpx port sync, and they were going to greatly enhance the RGBpx platform in general with new features. They never did any of that.
I also asked them if they could add a simple Marquee lighting effect which is a pretty common effect. They said if I sent them a video of the effect, they would add it. When I sent the video, they said they would not add that effect, or any new effect, and I should just pick another preset from the list. Aquacomputer's presets are pretty basic and some of them have controls that are quite unintuitive. There are other RGB control programs out there that can do so much more. I guess Aquasuite had to put out something to cover the RGB craze, but they don't seem interested in improving RGBpx. I don't think they are ever going to add RGBpx port sync across devices, so when you are assigning RGBpx ports, keep in mind that there is no sync between RGBpx ports across devices.
Note - The RGBpx ports on the Farbwek360 can stack effects with transparency, which is a very powerful feature. The RBBpx ports on the Quadro, Octo, and other devices do not support stacked effects with transparency. There are other differences, like the total number of RGB controllers that can be used concurrently. Check the owners manuals for details.
Molex - Most LED effects do not consume anywhere near the max current the LEDs can draw when set to worst case White at full brightness. Whether you need to worry about total current draw from the LEDs depends on what lighting effects you are using, and what you set the brightness to. The fan motors will draw more current than the LEDs. A standard 18AWG 2-foot long 4-pin Molex power cable can pass 6 to 8 amps per conductor. Max power is ~96 watts on the 12VDC conductors and 40 watts on the 5VDC conductors. I suggest wiring up one of your 8-fan groups and measuring the current draw on the 12V and 5V conductors with a DC Ammeter. Check it when the fans are at max speed, and with whatever lighting effects you are planning to use. It probably will not be as high as you think it is. Make your decision based on measured values. If you need more power and don't have another Molex output on your PSU, you could use a SATA to Molex adapter for the LEDs, bearing in mind that SATA power is limited to 22.5W on the 5VDC rail. Since the fan motors will draw more current than the LEDs, I would leave the fan motors on Molex power.