I have Asus x99 E-WS 10G, its truly wonderful broad ( and very $
) with my 10G Asus switches I can swap files on my home and offices network with extreme speed. The problem is the limitation of USB ports, there are only 3x USB 3 ports at the back, and 2 internal USB 2 headers but the bigger problem is that I'm on Windows 7 and unlike Windows10 have built in to OS USB 3 drivers Windows7 substitutes them with eXtensible host controller that doesn't work all that great and depend on some peoples habits, if they never put their system to sleep they are OK, but if you do like I do there are some issues that will not get resolved due to the windows 7 age.
The drivers work OK and the speeds of USB devices connected to the USB 3 ports are great but there drivers causing some issues especially on this board or I should say this platform, when you have any type of USB hub (USB 2 or 3) connected to any of the USB ports at the back with eXtensible host controller and drivers installed, it will randomly hang system when entering sleep mode, everything is running, the fans, lights the only thing is off is the monitor and it can happen within a day, 2-3 days, than I have to hard reboot because nothing is responsive.
Without the drivers installed the USB 3 speeds are like USB 2 but no hanging, so I simply run without the eXtensible host controller, I really don't need them and Intel and Asus won't update the drivers for windows 7 which I understand but I won't update my OS period......Windows 10 sucks majorly.
Anyways, the bigger problem is that I use a lot of programs outside of windows and keyboard and mouse need to be connected directly to the USB 2 or 3 and since I have on board USB 2 headers I also have USB 2 updater with bracket for M/B rear IO I would need to free the USB 2 header for that in which now is occupied by Aquaero USB 3 cable.
I work around all those obstacles since I got the board so I don't mind keep on doing it, but that's why I was wondering if its possible to do that so I could free the USB 2 header and use it to make things a bit easier for me, if won't work, well.....I will just keep on doing what I have been for the past year or so, no big deal