It may work, but it will be either warm or loud, wouldn't recommend.
I've used a i7-6700K (stock non-OC, 91 W TDP) + Titan X (Pascal, with +200/+600 OC, 300W TDP) with a single 45 mm thick 280 radiator, with two 140mm fans in push at ~800 rpm, for about 2 years (the first two pictures in
this post show my old rig).
During many hour long game sessions, GPU temperature rose to 55℃, with the water at approximately 43℃. This is considered warm, but should still be safe for the D5 pump, as far as I know (60℃ is the upper limit IIRC). Apparently warmer water promotes the release of plasticizer from the tubes into the water, which can clog the fins in water blocks, or so I read. This wasn't an issue for me personally, but I guess it can't hurt mentioning.
In the spirit of openness/honesty, I have to add that the single review I read of their (absolutely gorgeous!) airplex radical copper radiator had no nice words for it, which is a pity because I really dig its looks. To end on a positive note, I do love AC for their superb Aquaero and Aquasuite, and hopefully soon for their superb 2080 Ti GPU block as well.