Quoted from the product page of the AM4/3000/5000 version, with the difference being visible in the images.
When using the AM4/3000/5000 retention system, the water block is not centered on the CPU. Instead, the water block is installed slightly off-center for optimum heat dissipation in accordance with the modified internal design of the Ryzen 3000 and Ryzen 5000 series CPUs.
AM4
AM4/3000/5000