The aquabus is a simple data connection and does not offer the same feature set as a USB connection. A firmware update via aquabus is not possible. This requires a USB connection and aquabus can be connected too while doing this.

Please also note that the aquaero will manage the QUADRO/OCTO like it is a part of its own hardware. A possible issue is that if for example you want to use many curve controllers you are liimited to the four controllers of the aquaero while QUADRO/OCTO has its own curve controllers per channel but they can be only accessed via USB.

The aquabus low speed was using a different protocol so even if it would be still enabled, you would not be able to use it with any aquabus enabled device that we sell right now. All current hardware must be connected to the aqabus high(speed) port. This also includes QUADRO/OCTO of course. If you want to connect multiple devices you have to use a y-cable or splitter.