on top of what Infoseeker said, I'll also add it's probably a bad idea to daisy chain USB hubs, simply put, you are adding more traffic to the hub that's directly connected to the MB header.. Chance are you wont ever use the bandwidth to the fullest, unless you are plugging in USB drives or BT/Wifi devices, USB sometimes just loves to throw temper tantrums and make your computer behave erratically.
I only did this with the external USB3 hub to have better access when I need to plug in my sandisk USB3 ext thumb drive, it's a hub uplink to a hub, I don't keep anything plugged in and I dont have USB3 ports on my case, it's 5.5 yrs old
Both my NZXT hubs are connected to the MB, now if I remember correctly..
HUB 1 = 4 external USB ports on my case, Aquaero 6 Pro, Corsair LINK
HUB 2 = AC Pump X4, Farbwerk X2
I do have a full set (6) Power Adjust 3, which are connected to the AQ6 via Aquabus
to understand this better, you really need to dig into how USB works, laymen's term, apart from the actual trafic, device identification, head traffic, etc, etc, etc.. I can probably write a 2000 word paragraph explaining this but sometimes, keeping it simple is better. Think highways and cars, you have many cars on the secondary hub all shoving into the first hub, then you also have cars on the first hub, all shoving into the one highway going into the motherboard, chances are the result will cause your computer to act funny and do strange things.. BSOD even ? Renesas/NEC, Intel IMHO makes the best USB chips/drivers, Asmedia isn't too bad, which this board uses, drivers are good but can be temperamental with certain products, my old Logitech G19 hated the USB 3 port for some reason.
I don't use the external Asus overclocking panel, it was more of a novelty thing (just my $0.02), once I got the clocks to where I want it, it stayed there and looking at the numbers on the screen didn't make sense to me, I just found better use of the limited USB 2 port on the MB, maybe it's more useful for hard core tweakers and people wanting to run their CPU at 5.0ghz + 24/7
In my past experience, I always find that keeping it simple is good, less chance of problems, if you don't always use it, unplug it from the USB and plug in only if need, it helps.. You'd be surprise how many times I narrowed down root cause of problem to USB devices, another suggestion is if you can, connect USB2 devices to USB2 ports (they are black), USB3 (usually blue) is backward compatible, but I have trouble shooted issues in the past where moving a USB2 device from a USB3 port to USB2 resolved it, cough... HP PRINTERS....